Researchers at the University of Bristol, led by Dr Matthew Butler and Professor Simon Satchell, have developed a potential new blood test that could detect early kidney damage. Their study, published in Nature Communications and funded by Kidney Research UK and the Medical Research Council, focuses on the glycocalyx, a thin protective layer lining blood vessels in the kidneys that is damaged in conditions such as diabetes. When this layer becomes thinner, kidney filters become “leaky,” allowing protein to pass into urine. The team found that similar changes also occur on red blood cells, meaning a blood sample could reflect kidney vessel health. This could enable earlier diagnosis and treatment of kidney disease.
“We know the microscopic kidney blood vessels are damaged in the earliest stages in some kidney diseases, but they are largely inaccessible to us clinically. Detecting damage to these tiny blood vessels using a blood test would allow us to identify signs of kidney disease earlier than ever before.” Dr Matthew Butler.
“These results show a blood test could be used to identify signs of disease affecting the kidneys at a much earlier stage. Earlier identification is key to making proactive interventions to protect kidney health and improving outcomes for patients.” Professor Simon Satchell.
Would you have found this blood test helpful if it had been available to you?